Babli was trying to understand the role of actin in tissue mechanics during Drosophila embryogenesis during her internship in Prof. Adam Martin’s lab at Massachusetts Institute of Technology. Multicellular organisms originating from a single cell, has to undergo a myriad of mechanical transformation to acquire its final form and function. Epithelial cells in embryo have polarized actomyosin structures acting as ropes which are responsible for stable contractile force generation to undergo desired mechanical change. How do the differential levels of actin and its dynamics regulates cellular constriction, stretching or intercalation across a tissue is not yet understood properly. She aimed to answer these questions using various gene knockdown experiments along with destabilizing actin dynamics using drugs and finally supporting the data with quantification modeling. Understanding this behavior can have a direct implication to understand and treat various diseases related to development as well as angiogenesis which involves similar tissue mechanics.
Richa is researching the synthesis and characterization of 2D materials. She will be using high temperature vacuum furnaces to grow GaSe thin film. And, then she will characterize the grown materials using Atomic force microscopy, Raman Spectroscopy and Photoluminescence spectroscopy she will characterize these materials and their opto-electronic properties.
2018 Khorana Scholar who worked with Aseem Ansari. In the lab, Aimen is Establishing Reporter Lines for detecting Friedreich Ataxia (FXN) Gene Reactivation in Human Neural Cells using the CRISPR/ Cas9 Genome editing method.
2018 Khorana Scholar who worked at John Hopkins University under Professor Trina Schroer.
“The focus of my project is to study cargo binding and regulation of Cytoplasmic Dynein motor and Dynactin. It involves development of TetR-shRNA constructs for inducible knockdown of targeted subunits of the Dynactin complex and analysis of its effects on the cargo binding ability of the Dynein-Dynactin-Activating Adaptor Complex, using live cell imaging. Simultaneously, it also involves studying the effects of mutations at sites of phosphorylation of the p25 subunit of the Dynactin complex on cargo binding and other phenotypes like cell cycle progression and primary cilia-genesis.”
2018 Khorana who worked with Yiping Qi. “I improve plant genome editing tools using molecular biology techniques to simplify genetic manipulation of crop plants. Specifically, these tools like base editors and CRISPR based tools are for activation and/or repression of targeted genes.”
Richa’s research is “NON UREMIC CALCIPHYLAXIS” highly fatal and extremely rare disease of “ Non Uremic Calciphylaxis ”, which has a reported mortality rate of 81% within 6 months of diagnosis , which is much more than many of the stage IV malignancies. It is an ischaemic vasculopathy characterized by the deposition of calcium within the media of small and intermediate dermal vasculature which can lead to epidermal ischaemia , ulceration and necrosis. It is usually seen in end stage kidney disease patients but i am working on that disease that develops in non kidney disease patients.
2018 Khorana Scholar who went to Northwestern University and worked under William Klein.
My main project is “Studies of brain cell loss caused by the toxic amyloid beta oligomers linked to Alzheimer’s dementia.” I am working on two things: one is to study the role of amyloid beta oligomers in the CNS development; the other one is to confirm the binding of synthetically produced fluorescent peptides with the amyloid beta oligomers.
I’m a 4th year MD/PhD dual degree student, currently working towards my PhD in Epidemiology. My research interests are in the area of healthcare-associated infections, especially those related to antibiotic resistance and Clostridium difficile globally. Outside of work I enjoy cooking, photography, reading, and travel.
I worked with Prof. Aravinthan Samuel at Harvard University. I performed analyses of courtship and mating in C. elegans to better understand the neural basis of decision making in a small circuit with a complete connectome. My discoveries by performing experiments between C. elegans males and hermaphrodites of different genetic backgrounds highlighted new aspects of sensory perception.
2018 Khorana Scholar who worked with Georg Jander. His project was “Maize-insect interactions : Study of corn leaf aphid(Rhopalosiphum maidis) or in general insect induced genes in maize lines. Mainly genes like bx1/bx2 and involved in synthesis of benzoxazinoids and terpenes defense volatile compunds respectively against insects and various pests.”
Vishal is researching the detection of morphological differences in tissues in the context of osteoarthritis. His project is based on the registration of two images to analyse effect of bone development in osteoarthritis.
Sourav researched on “Polyhydroxyalkanoates production from methanotrophic and non-methanotrophic organisms”. He collected information on how microorganisms accumulate biopolymer inside their cell. The biopolymers can be extracted and purified from the microorganisms. All these factors will be helpful to facilitate the industrial scale production of polyhydroxyalkanoates.
Ishu is researching on estimating the structure and motion from Videos. He will be using Deep Neural Networks to train a model that decomposes frame-to-frame pixel motion in terms of scene and object depth, camera motion and 3D object rotations and translations. The model when trained can be used to predict depth maps from the single monocular 2-d image and predict the pose and motion from two consecutive images of the video.
I did my summer research internship at the University of Illinois at Urbana-Champaign under the guidance of Prof. Chad Rienstra. My project was on the quest of searching lattice structure and dynamics of celebrated antifungal drug Amphotericin-B (AmB) and its interaction with Cholesterol and Ergosterol. The motivation of this project was to understand the working mechanism of the drug inside a cell. Since AmB is also a nephrotoxin and kills good cells (presumably by binding with Cholesterol) besides killing fungal cells (binding with Ergosterol), a modified structure of AmB for targeted functionality is necessary. I used solid-state NMR data of AmB from various experiments and conducted molecular dynamics simulations with restraint inputs from the NMR NOE data. I’m currently continuing to contribute to the project by doing Density Functional theoretic calculations to understand UV-Vis spectrum of the AmB lattice.
Mohit worked on Active Flow Control for drag reduction due to wall turbulence. He was using blowing/suction actuation to suppress the turbulent coherent structures in the flow. The flow bed had an array of sensors to detect the pressure fluctuations at the wall and blowing/suction will be performed accordingly. To design the experimental setup, simulations were performed using resolvent Spectral method.
Pallav is studying Invariant Theory of General Linear Groups over Finite Fields – They are trying to describe the generators of the invariant ring of general linear groups over finite fields due to their action on a quotient subring of the polynomial ring
Daniel Howard, a 2015 S.N. Bose scholar, spent his summer in Bengaluru, India at the Tata Institute of Fundamental Research, Centre for Applicable Mathematics (TIFR-CAM) with Prof. Praveen Chandrasekhar. Collaborating with Prof. Dinshaw Balsara from the University of Notre Dame, research work focused on computatonal fluid dynamics and discontinuous Galerkin methods. Daniel received his B.S. in Applied Mathematics, Engineering, and Physics (AMEP) from the University of Wisconsin-Madison in May 2015 and is now a Ph.D. graduate student at the University of Notre Dame in the Department of Applied & Computational Mathematics & Statistics (ACMS).
Kanika is studying the production of biofuels using Zymomomas using MEP pathway which is used to make isoprenoid. They are trying to clone 5 enzymes of this pathway and incorporate this plasmid into zymomonas for bioduels biofuels production
Ananth is studying polymer conformations in ionic liquids. The aim of the project is to find the dependence of polymer size on the molecular weight, when the polymer is dissolved in an ionic liquid. The polymers studied are PEO and NIPAM. The studies will be conducted using rheology and light scattering techniques.
The Klein Lab discovered that amyloid-beta oligomers (AβOs) causes neuronal death and ultimately dementia in Alzheimer’s disease. My research was on understanding the cellular and subcellular localization of AβOs in isolated CNS neurons. This was done by isolating neurons from chick embryo retina and performing immunocytochemistry to check the distribution and localization of AβOs . AβOs were found mainly in ganglion cells and subcellularly found in cell body and processes of the neurons.
Anuja’s project is studying a norovirus is the most common cause of gastroenteritis in the world. The ORF1 of this virus encodes a polypeptide which is cleaved by a protease to form non structural proteins. The project is to study the effect of various protease inhibitors on the Houston variety of this virus (HOV) and find the most potent inhibitor of HOV protease.
Vivek’s lab is called “The Effect on the size distribution of the Nano-particles by the application of DC as well as AC Electric field to the Flame System with different geometry”. Along with this they will also focus on doing charge fraction, size distribution measurement, and SEM TEM imaging of Nano-particles.
The topic that Rhaul is studying is Rhodopsin Biosynthesis and Disc Formation in Rod Photoreceptor cell Description: Photoreceptor cells are a specialized type of neuron found in the retina that absorb and convert photons into electrical signals. They are essential for initiating the phototransduction cascade, which ultimately leads to visual perception. There are two types of photoreceptors: rods and cones. Rods are located in the outer regions of the retina and allow us to see in dim light as well as dark conditions. Rhodopsin is the light sensitive visual pigment in rods that allows humans to see in these low light conditions. Cones, on the other hand, reside mostly in the central portion of the retina and allow us to perceive fine visual detail and color. Both rods and cones are comprised of an outer segment full of discrete membranous discs, an inner segment, a nuclear layer, and a synaptic terminal. My project focuses on understanding rhodopsin biosynthesis and disc formation patterns in rod outer segments (ROS). It is widely accepted that disc formation in mammalian rods follows a 10-day cycle and light exposure increases disc phagocytosis at the apical end and increases lipid production at the basal end. Phagocytosis and degradation of ROS ensures functional integrity of the photoreceptor cells and other retinal cells. There are several factors, such as genetic or environmental factors, that can cause photoreceptor degeneration and eventual vision loss. Currently I am exploring how varying light conditions impact ROS renewal and rhodopsin incorporation into discs. Using a transgenic mouse that has a fluorescent marker attached to rhodopsin, I aim to understand the pattern of disc formation, rhodopsin biosynthesis in ROS, and the degenerative effect of light. This project can provide insight on how light exposure affects photoreceptors structure and function, which plays a key role in the visual process.
Jared Landsman is an MS student in the Building Science program at UC Berkeley. He received his BS in Civil Engineering from Cornell University in 2014. Through the Center for Building Energy Research and Development (CBERD), Jared is currently conducting research on occupant comfort and the performance of passive design strategies in buildings in both the United States and India. This past summer, Jared spent 6 weeks working with the Centre for Advanced Research in Building Science & Energy (CARBSE) at CEPT University in India.
2018 Khorana Scholar who worked at the University of Wisconsin Madison under Professor Jo Handelsman.
Shruthi studied genetic analysis of microbial community and invasion. In which I am working on developing a stable model community and will identify the genetic determinants of synergistic community assemblages using this model community.
2018 Khorana Scholar who worked with Nitish V. Thakor. “I am working on building a mixed reality training program for upper limb amputees and providing them a proprioceptive feedback of their arm location.”
“We are using a novel Separase inhibitor Sepin-1 developed by Dr. Pati’s lab to treat Neuroblastoma tumors. We will be injecting Sepin-1 into NB mouse model and check it’s anticancer activity. The last step would be to perform IND enabling studies.”
Murlidhar is fabricating scaffolds from blend of natural cell-interacting chitosan and lactide-polyethylene gylcol hydrogel followed by characterization of hydrogels which can further used for encapsulation of MSCs.
Sibendu is studying the ffective SINR measurement for wifi OFDM PHY layer abstraction. Actually present PHY layer abstraction has a default AWGN channel so we have a constant frequency independent SINR but to avoid interference and multi path fading we go for OFDM where a number of subcarrier frequency bands used to send parallel bit stream. So here SINR will be different in each frequency band so we get a SINR vector that we are trying to map in a single SINR by EESM and MIESM algorithm. The entire implementation will be done in NS3 where the SISO (Single Input Single Output) model exist so from the SINR vector got from MIMO model we will have a single SINR so that it can be equivalently fitted in that SISO.model
Jacob is studying multiple vulnerabilities among People Who Inject Drugs (PWIDs) – This research focuses on the scope for primary prevention among PWIDs in their injecting as well as sexual networks. This work also looks into scope for integrating sexual reproductive health services with maternal and child health services. He finds this topic very interesting looking at India’s HIV control programme (which looks at prevention programmes aimed at high risk groups for HIV) at one hand,and the existing social cultural structure with patriarchy and status of women and how these affect access to health on the other to understand various dimension of vulnerabilities for transmission in the population.
Amartya studied the effect of drug-mediated metabolic stress on lipid droplet (LD) abundance, one of the major hallmarks of cancer. His experiments showed a significant alteration in the LD abundance post drug treatments in major cell lines of triple-negative breast cancer, the most aggressive form of breast cancer.
Poovizhi Rengasamy is studying the simulation and implementation of voltage quadrupler. For the purpose of electrofishing 240V AC generated in the boat is converted to 1200 V DC using power electronic switches.The simulation is done using PLECS software and has to be implemented in PCB board.Earlier the conversion from AC is done using manual switches and huge capacitors. After using power electronic circuit we are able to achieve the conversion with less capacitance values and also control can be done in the final output voltage which is also cheaper.
Suriya is studying MR reconstruction using deep learning. Use of compressed sensing techniques allows MRI reconstruction from undersampled sparse K space data.To explore the use of specialised convolutional neural networks and autoencoders to learn optimal regulizers in reducing the motion artifacts and also reducing the computational time in compressed sensing based CEST(chemical energy saturation transfer) MRI reconstruction.
“The Effect of Hepatits B Status on Drug Induced Hepatotoxicity from Anti-Tuberculosis Treatment” — Treatment with antituberculosis medications often induces hepatotoxic effects, deemed drug induced hepatotoxicity. This can cause serious liver damage, increase likelihood of default, and complicate treatment. Chronic Hepatitis B co-infection is hypothesized to exacerbate this side effect. The Tibetan refugee population in India has both a high burden of Hepatitis B and Tuberculosis and thus provides a unique opportunity to study the interaction between these two diseases.
Yashovardhan’s proj is called et name is “Dynamic Searchable Encryption via Blind Storage”. He will be working on implementing and improving a solution developed by his professor to the problem of “Symmetric Searchable Encryption. He will be considering various security, efficiency and usability aspects of this construction.
Shashank was researching on recent changes in glaciers with respect to mass budget and flow dynamics in Sikkim, India as a part of the ‘NASA High Mountains of Asia Project’. He used medium to high resolution satellite images to derive DEMs and work on a time series using open source libraries. Additionally, he assessed the galcial lakes in the region and try to establish a link between glacier dynamics and lake growth pattern.
2018 Khorana Scholar who worked at Northwestern University under Professor Yuan Yang. Nirvik is looking into the investigation of detection threshold for transcutaneous electrostimulation in CVA patients and healthy individuals- a comparative study of the effects of gender, age and subcutaneous fat.
Soundarya’s project area is the Process Engineering and Energy. Brief description: It deals with supply chain management and finding the most optimized way for producing biofuel using regioanl depots and GAMs software.
2018 Khorana Scholar who worked at Duke University under Ashutosh Chilkoti.
“I’m working on exploring the use of recombinant polypeptide to deliver platinum based anticancer therapeutics using Elastin like polypeptide (ELP). This involves cloning of bacteria, including its transformation with plasmids, plasmid extraction along with the expression of the protein in the transformed bacteria. This will be followed by characterisation of the protein and its conjunction with anti-neoplastic drugs.”
Santhoshini is studying approximating MAXDICUT in a streaming setting – They are working on finding a good approximation algorithm for finding Max DICUT of a directed graph with its edges coming in a streaming setting and they are working on lower bounds for the same
Sridevi is studying homeostatic plasticity in cultured visual cortical neurons: The aim of the project will be to transfect cultured visual cortical neurons with a lentiviral construct expressing a mutant form of GRIP, a post synaptic protein and study the effect on homeostatic plasticity.
I went to India this past summer to complete my field work for my Masters in Public Health program. I did a qualitative research project on antibiotic resistance. I enjoyed learning more about public health along with learning about the Indian culture.
Sai Sinhu is working on Biosensors for small molecules based on Transcription Factors. They have transcription factor gene and a GFP transformed into a bacterial cell. So when the transcription factor goes and binds to promoter of GFP , the GFP is repressed. When the small molecule binds to transcription factor, it leaves the promoter making space for RNA polymerase to bind and GFP is expressed. So this GFP on Off helps us to sense how much small molecule is produced in the cell. I am checking which promoter for transcription factor will give us a good on-off signal. So they selected promoters which have diverse distributed protein production units and planning to transform them into bacterial cells and see how the GFP on off works.