“What could we do with layered structures with just the right layers? What would the properties of materials be if we could really arrange the atoms the way we want them …” These words from Richard Feynman started the scientific world down the path to discover 2D materials. Dr. Robinson’s interests span a wide range
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Ignacio joined the Chemistry faculty at the University of Rochester in July, 2013. Ignacio received his B.Sc. in chemistry from the National University of Colombia in 2001. In 2002, after completing the diploma program in condensed matter physics at The Abdus Salam International Centre for Theoretical Physics in Trieste, he moved to the University of Toronto
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Aindrila Mukhopadhyay leads a multidisciplinary team to study stress response in bacteria using microbiological, biochemical and systems biology tools. As part of JBEI’s Fuels Synthesis Division, Dr. Mukhopadhyay is the Director of Host Engineering. Her projects include the study of two component signal transduction systems in the anaerobic sulfate reducing bacterium Desulfovibrio vulgaris Hildenborough and
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Our laboratory seeks to understand the mechanistic logic of assembly line polyketide synthases, and to harness these insights in order to engineer new antibiotics. The prototypical system of interest to us is the 6-deoxyerythronolide B synthase, which synthesizes the macrocyclic core of erythromycin. Other examples of antibiotic biosynthetic pathways under investigation in our laboratory include
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My research interests focus on the design and discovery of synthetic, and natural product inspired small molecules which can be used as probes for developing understanding of biological phenomena, including protein-protein interactions and modulation of signal transduction pathways. My laboratory employs the tools of synthetic medicinal chemistry, molecular modeling and chemical biology for translational research
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Our laboratory focuses primarily on the development of ligand-targeted imaging and therapeutic agents for the diagnosis and treatment of important human diseases. First, we are designing, synthesizing and testing targeting ligands for their abilities to deliver attached drugs specifically to pathologic cells, avoiding unwanted uptake by healthy cells. Because a receptor for the ligand, folic
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Dr. O’Halloran’s research interests center on the regulatory biology and chemistry of transition metal receptors involved homeostasis and oxidative stress pathways. His work focuses on the intracellular chemistry of elements essential for growth and proliferation, (i.e. zinc, copper and iron), nanoscale drug delivery mechanisms and on the mechanisms of clinically important anticancer agents that are
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Research Description Proteins often utilize small folded domains for recognition of other proteins, DNA and RNA. The hypothesis guiding our research is that by mimicking these folded domains we can modulate the function of a particular protein with metabolically stable synthetic molecules. The manifestation of this hypothesis into specific and potent compounds that interfere with
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Nanotechnology is fueling our exponentially growing knowledge of genome structure, populations, and ourselves. This new biology is melding computation with experimental systems that are increasingly miniature, comprehensive, information-dense, and capable of dealing with complexity. Within this environment we create fully-integrated systems for discovery and use them for uniquely revealing genome structure / function relationships, and
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Work in the Distefano Group on protein prenylation is focused in two areas: Chemical Biology and Biotechnology Applications. In pursuit of those studies, members of the group perform a variety of different types of experiments including chemical synthesis, biochemistry, proteomics and cell culture and animal-based work. The goal of this work is to gain insight
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