Feyza Engin

Research Area

Biomolecular Chemistry

Institution

University of Wisconsin-Madison

The main goal of the laboratory is to understand the role of organelle stress in the pathogenesis of diabetes. We are particularly interested in examining the β-cell Endoplasmic Reticulum (ER) Stress and Unfolded Protein Response (UPR) in the context of autoimmune diabetes. We use numerous interdisciplinary approaches, including biochemistry, molecular biology, genetics, cell biology, molecular biology and immunology in our in vitro and in vivo studies.

By using novel mouse models and cutting edge experimental systems such as Seahorse metabolic flux analysis, electron microscopy, FACS analysis and imaging techniques, we aim to identify the molecular mechanisms of stress induced diabetes with the ultimate goal of development of better and more effective therapeutic approaches for this disease.

For more information please visit our lab webpage:
http://enginlab.org