Biomedical Engineering, Systems and Synthetic Biology
Rice University
We are interested in understanding overall organization of biochemical networks involved in stress-sensing and responding in particular model systems as well as formulating general principles of stress-response across bacterial species. We want to understand the evolutionary design principles of these networks by in correlating these variations with the different regulatory demands. In particular, we are interested in the networks characterizing bacterial sigma factors and two-component systems — two widespread mechanism of master level regulation of bacterial gene expression.