We are interested in RNA processing events that are unique to trypanosomes and could be exploited as targets for the design of therapies against protozoan diseases. To date, the Protozoa are responsible for the infection and death of millions of people worldwide. I am especially interested in two facets of RNA processing in trypanosomes: tRNA
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Dr. Muthusamy’s research interests are focused on the following areas: 1) Biological therapies for hematological malignancies with primary focus on acute and chronic leukemia; 2) Development and characterization of clinically relevant animal models of lymphoid malignancies; 3) Targeted delivery of RNA based therapeutics in lymphoid and myeloid malignancies. Research Interest Leukemia, Lymphocytic, Chronic, B-Cell, Cancer,
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Major Areas of Research Examine interactions between the immune and nervous systems in regulating viral pathogenesis in the central nervous system (CNS) Determine the mechanism by which innate immune responses in neurons induce neuronal apoptosis and the role of SARM1 in this process Identify the mediators of blood-brain barrier breakdown during La Crosse virus infection
Read MoreOur research interests include designing materials and devices to address energy and environmental challenges, especially electrochemical energy storage & conversion, and thermal energy harvesting & management. The research activities involve exploration of novel materials and chemistry for advanced energy storage, development of high-performance catalysis, advanced materials and devices for thermal energy harvesting and management, and
Read MoreEarly stages in modern drug discovery often involve screening small molecules for their effects on a selected protein target or a model of a biological pathway. In the past fifteen years, innovative technologies that enable rapid synthesis and high throughput screening of large libraries of compounds have been adopted in almost all major pharmaceutical and
Read MoreWe are the Vector Genetics and Control Laboratory at the Pennsylvania State University. We work at the interface of mosquito genetics and vector-borne disease control. Our lab integrates population biology, ecology, molecular tools and theory to address fundamental and applied questions related to vector arthropods and the pathogens they transmit, with emphasis on release of
Read MoreOur overarching interest is in the question of how experience and deprivation modify synaptic connections in the brain. Experience-dependent synaptic plasticity is the physical substrate of memory, sculpts connections during postnatal development to determine the capabilities and limitations of brain functions, is responsible for the reorganization of the brain after damage, and is vulnerable in
Read MoreWe study communication within the cell. Our primary goal is to understand how signals and molecules are transmitted between nucleus and cytoplasm across the nuclear envelope. We are deciphering the mechanism and structure of the cellular machinery that executes these cellular processes. Malfunctioning of nucleo-cytoplasmic communication leads to a wide range of prominent human diseases,
Read MoreThe Wong Lab seeks to understand mechanisms employed by cells and tissues to maintain metabolic homeostasis. We are currently addressing how adipose- and skeletal muscle-derived hormones (adipokines and myokines), discovered in our lab, regulate tissue crosstalk and signaling pathways to control energy metabolism. We use transgenic and knockout mouse models, as well as cell culture
Read MoreWork in the Schroer lab addresses questions of cell motility: movement within the cell and movement of the cell as a whole. Our focus is on the microtubule cytoskeleton, the motors that power movement, and the cargo structures and molecules with which motors interact. Much of our work is focused on the cytoplasmic dynein motor,
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