Biology, Cell Biology, Structural Biology
Massachusetts Institute of Technology
We study communication within the cell. Our primary goal is to understand how signals and molecules are transmitted between nucleus and cytoplasm across the nuclear envelope. We are deciphering the mechanism and structure of the cellular machinery that executes these cellular processes. Malfunctioning of nucleo-cytoplasmic communication leads to a wide range of prominent human diseases, including viral infections, neuromuscular diseases and many more. We use a diverse array of techniques, including structural, cell biological, and genetic methods, to support our quest for exciting and fundamental discoveries in biology.