Anuja’s project is studying a norovirus is the most common cause of gastroenteritis in the world. The ORF1 of this virus encodes a polypeptide which is cleaved by a protease to form non structural proteins. The project is to study the effect of various protease inhibitors on the Houston variety of this virus (HOV) and find the most potent inhibitor of HOV protease.
“We are using a novel Separase inhibitor Sepin-1 developed by Dr. Pati’s lab to treat Neuroblastoma tumors. We will be injecting Sepin-1 into NB mouse model and check it’s anticancer activity. The last step would be to perform IND enabling studies.”