Babli was trying to understand the role of actin in tissue mechanics during Drosophila embryogenesis during her internship in Prof. Adam Martin’s lab at Massachusetts Institute of Technology. Multicellular organisms originating from a single cell, has to undergo a myriad of mechanical transformation to acquire its final form and function. Epithelial cells in embryo have polarized actomyosin structures acting as ropes which are responsible for stable contractile force generation to undergo desired mechanical change. How do the differential levels of actin and its dynamics regulates cellular constriction, stretching or intercalation across a tissue is not yet understood properly. She aimed to answer these questions using various gene knockdown experiments along with destabilizing actin dynamics using drugs and finally supporting the data with quantification modeling. Understanding this behavior can have a direct implication to understand and treat various diseases related to development as well as angiogenesis which involves similar tissue mechanics.
The joy of getting answers to all hows that came to my mind is what made me realise that I would have more fun finding answers to the unanswered questions out there. I am Neelima P V and I am doing my master’s degree in life sciences from CEBS Mumbai. I am inquisitive, hardworking and passionate about knowing more about how cells work alone and in a group and the possibilities such info put forth. I am looking forward to seeing where this passion takes me in my research career.
I am a Student of Life Sciences. I did my B.Tech in Biotechnology and doing M.Tech in Bio-Pharmaceutical technology from Anna University, Chennai, India (a premier University of South India). I am interested in understanding the underlying mechanisms of diseases and finding a cure for the same. I am fortunate to be mentored by Dr. Graham C Walker at MIT, Boston, USA. I will be guided on “Synthesizing mutagenic TLS in mammalian cells and its inhibition as a way to improve chemotherapy”. I thank Winstep for organizing this fellowship and eagerly waiting to join the lab soon.