2018 Khorana Scholar who worked with Aseem Ansari. In the lab, Aimen is Establishing Reporter Lines for detecting Friedreich Ataxia (FXN) Gene Reactivation in Human Neural Cells using the CRISPR/ Cas9 Genome editing method.
Aindrila worked on the “Characterization of HCN1 – hEAG1 chimeras using electrophysiology” in Prof. Baron Chanda’s lab at the Wisconsin Institute of Medical Research, University of Wisconsin-Madison for the summer, 2017. She was using Human Embryonic Kidney Cells (HEK 293) as a model system to record the electrical properties of the chimeric ion channels consisting of critical segments of HCN1 and hEAG1 by patch clamp in whole cell configuration. This project will help her understand what is the critical portion in the primary structure of HCN1 channel (hyper polarization activated cyclic nucleotide gated channel) that is responsible for making it an inward rectifier channel despite of structural similarity with a common potassium channel hEAG1 (human Ether-a-go go1) which is an outward rectifier channel.
Daniel Howard, a 2015 S.N. Bose scholar, spent his summer in Bengaluru, India at the Tata Institute of Fundamental Research, Centre for Applicable Mathematics (TIFR-CAM) with Prof. Praveen Chandrasekhar. Collaborating with Prof. Dinshaw Balsara from the University of Notre Dame, research work focused on computatonal fluid dynamics and discontinuous Galerkin methods. Daniel received his B.S. in Applied Mathematics, Engineering, and Physics (AMEP) from the University of Wisconsin-Madison in May 2015 and is now a Ph.D. graduate student at the University of Notre Dame in the Department of Applied & Computational Mathematics & Statistics (ACMS).
Dhiman worked on computational analysis of nano-bio interface from molecular dynamics simulation. The charge of nanoparticles influences how they interact with biomolecules. He used molecular simulation techniques with classical force fields to study the charge and mobility of nanoparticles in presence of external electric field and make predictions which can be compared with experiments.
Jacob is studying multiple vulnerabilities among People Who Inject Drugs (PWIDs) – This research focuses on the scope for primary prevention among PWIDs in their injecting as well as sexual networks. This work also looks into scope for integrating sexual reproductive health services with maternal and child health services. He finds this topic very interesting looking at India’s HIV control programme (which looks at prevention programmes aimed at high risk groups for HIV) at one hand,and the existing social cultural structure with patriarchy and status of women and how these affect access to health on the other to understand various dimension of vulnerabilities for transmission in the population.
Kanika is studying the production of biofuels using Zymomomas using MEP pathway which is used to make isoprenoid. They are trying to clone 5 enzymes of this pathway and incorporate this plasmid into zymomonas for bioduels biofuels production
Mohit worked on Active Flow Control for drag reduction due to wall turbulence. He was using blowing/suction actuation to suppress the turbulent coherent structures in the flow. The flow bed had an array of sensors to detect the pressure fluctuations at the wall and blowing/suction will be performed accordingly. To design the experimental setup, simulations were performed using resolvent Spectral method.
Pallav is studying Invariant Theory of General Linear Groups over Finite Fields – They are trying to describe the generators of the invariant ring of general linear groups over finite fields due to their action on a quotient subring of the polynomial ring
Poovizhi Rengasamy is studying the simulation and implementation of voltage quadrupler. For the purpose of electrofishing 240V AC generated in the boat is converted to 1200 V DC using power electronic switches.The simulation is done using PLECS software and has to be implemented in PCB board.Earlier the conversion from AC is done using manual switches and huge capacitors. After using power electronic circuit we are able to achieve the conversion with less capacitance values and also control can be done in the final output voltage which is also cheaper.
Prerna used CRISPR gene editing technology to study the functions of certain membrane trafficking proteins in the early secretory pathway. She worked on screening cell lines for functional proteins which have a detectable tag edited into them using Western Blot and Confocal Microscopy techniques. After that, she used live cell imaging to view these proteins and understand their function.
Sai Sinhu is working on Biosensors for small molecules based on Transcription Factors. They have transcription factor gene and a GFP transformed into a bacterial cell. So when the transcription factor goes and binds to promoter of GFP , the GFP is repressed. When the small molecule binds to transcription factor, it leaves the promoter making space for RNA polymerase to bind and GFP is expressed. So this GFP on Off helps us to sense how much small molecule is produced in the cell. I am checking which promoter for transcription factor will give us a good on-off signal. So they selected promoters which have diverse distributed protein production units and planning to transform them into bacterial cells and see how the GFP on off works.
Shashank was researching on recent changes in glaciers with respect to mass budget and flow dynamics in Sikkim, India as a part of the ‘NASA High Mountains of Asia Project’. He used medium to high resolution satellite images to derive DEMs and work on a time series using open source libraries. Additionally, he assessed the galcial lakes in the region and try to establish a link between glacier dynamics and lake growth pattern.
2018 Khorana Scholar who worked at the University of Wisconsin Madison under Professor Jo Handelsman.
Shruthi studied genetic analysis of microbial community and invasion. In which I am working on developing a stable model community and will identify the genetic determinants of synergistic community assemblages using this model community.
Soundarya’s project area is the Process Engineering and Energy. Brief description: It deals with supply chain management and finding the most optimized way for producing biofuel using regioanl depots and GAMs software.
Sriraksha worked under Prof. Paul Voyles at the Materials Science and Engineering department at UW-Madison. She synthesized metallic glass thin films by sputtering. She also worked on characterizing them by nano-indentation and X-ray photoelectron spectroscopy techniques.
Sudharsan was researching to understand the role of FMRP & FXR2P genes in the neurogenesis, a process affected in a number of neurological and neuropsychiatric disorders, including fragile X syndrome. His lab was attempting to figure out whether removing Fmrp in progenitor cells or immature neurons (DCX+ cells) harms their development in any way. He does genotyping and sectioning the brains using sliding microtome to mount the sections & trace neurons using Apotome microscope
Vimal, a medical student from the University of Wisconsin Madison who majored in Molecular and Cellular Biology is going to Dr. Shroff’s Charity Eye Hospital in Daryaganj, Delhi to work with Sunita Arora. Vimal is going to too evaluate the impact of COP program on ophthalmic service delivery at SCEH and on quality of life of COP Graduates post one year of employment.