PROMOTING SCIENCE AND TECHNOLOGY BETWEEN INDIA AND THE U.S.
Biochemistry, Cell Biology, Pathology
Baylor College of Medicine
Main focus of our research program, largely funded by NIH and Welch foundation, is to understand structure-function relationships in medically important viruses with a clear emphasis on using this knowledge to develop/design effective antiviral drugs. Our structure-function studies are mainly focused on three human pathogens: Rotaviruses, which are major pathogens of infantile gastroenteritis; Noroviruses in Caliciviridae (NIAD priority B biodefense pathogen), which cause epidemic diarrhea in humans; and influenza viruses (NIAD priority C biodefense pathogen), which cause seasonal and pandemic flu.
Our approach is to use a variety of structural techniques including cryo-electron microscopy and X-ray crystallography along with various