Biochemistry, Cell Biology, Pathology
Baylor College of Medicine
Main focus of our research program, largely funded by NIH and Welch foundation, is to understand structure-function relationships in medically important viruses with a clear emphasis on using this knowledge to develop/design effective antiviral drugs. Our structure-function studies are mainly focused on three human pathogens: Rotaviruses, which are major pathogens of infantile gastroenteritis; Noroviruses in Caliciviridae (NIAD priority B biodefense pathogen), which cause epidemic diarrhea in humans; and influenza viruses (NIAD priority C biodefense pathogen), which cause seasonal and pandemic flu.
Our approach is to use a variety of structural techniques including cryo-electron microscopy and X-ray crystallography along with various