Jefferson Perry

Research Area

Biochemistry, Biochemistry & Molecular Biology, Cellular Mechanism of Disease, Neuroscience


University of California, Riverside

The Perry laboratory has an interest in the biochemical processes of signal transduction pathways and of genome stability, which in pathological states have clear relationships to cancer, rapid-aging disorders and neurological disease. We are also focusing our research on eye diseases, including processes involved in cataract formation and in macular degeneration. We use a range of structural biology and biophysics techniques to reveal key insights at atomic resolutions into the roles of cellular proteins under study. These include x-ray crystallography and in solution small angle x-ray scattering technologies, which we couple to biochemistry studies and measurements of binding affinities using isothermal titration calorimetry and microscale thermophoresis, to help further define molecular mechanisms. Our research also has a translational aspect, where we are developing novel small molecule chemical tools to help uncover molecular and cellular functions of the proteins of interest. These small molecules may have utility for the development of novel diagnostic markers, or as hit compounds/therapeutic leads in certain circumstances. Here, we use rational-based drug discovery methods that includes fragment-based ligand screening and computer aided drug discovery methods, to help identify and/or generate small molecules of interest. For more information on our research, please contact Dr. Jeff Perry at

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