PROMOTING SCIENCE AND TECHNOLOGY BETWEEN INDIA AND THE U.S.
Chemistry, Computational protein design
University of Michigan
“Unlike random heteropolymers, proteins fold into unique ordered structures guided by their amino acid sequence. In the folded states proteins are not static but undergo structural changes in response to change in the pH, ligand binding, etc. that governs their function. Understanding the detailed mechanisms underlying these processes is essential to complete knowledge of protein structure and function. To address these questions, we use molecular simulation, statistical mechanics, molecular modeling and massive computational resources.”