PROMOTING SCIENCE AND TECHNOLOGY BETWEEN INDIA AND THE U.S.
Biochemistry
University of Wisconsin-Madison
Research interests include protein-nucleic acid interactions, including kinetics and mechanism of transcription initiation, characterization of DNA wrapping in protein DNA complexes, development of small molecule solutes as thermodynamic and mechanistic probes of protein and DNA conformational changes. To study these processes, we use chemical and enzymatic DNA footprinting, microcalorimetry, circular dichroism, fluorescence, nitrocellulose filter binding, rapid mix-quench kinetics, and structural modeling.