Biochemistry, Biochemistry & Molecular Biology, Molecular Biology
University of Wisconsin-Madison
Many classes of DNA rearrangements occur in all cells and play important roles in gene regulation, development, carcinogenesis, and evolution. The goal of this laboratory is to understand how these genetic rearrangements come about, and how they are regulated. To this end, we study a range of bacterial enzymes involved in recombinational DNA repair, both in vivo and in vitro. Part of the effort involves screens to identify relevant enzymes with new and sometimes unanticipated functions. In addition to understanding the enzymes themselves, we are increasingly exploring the intersection of recombination with other processes in DNA metabolism, and seeking an understanding of the factors that limit recombination within a cell.