Biochemistry, Molecular Biology
Baylor College of Medicine
Our laboratory works at the intersection of three fields: epigenetics, top down proteomics and cancer. We use cutting edge top down proteomics tools to study the proteoforms of histones, transcription factors, nuclear receptors, co-activators/co-repressors, and chromatin ‘readers’, ‘writers’ and ‘erasers’. This proteoform level analysis of chromatin provides new insights into how chromatin regulatory mechanisms work and inform potential therapeutic strategies for cancer.